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Molecular Biology Technical Services
Molecular Biology Technical Services
Molecular biology focuses on the understanding of the interactions between different systems in a cell, including the relationship between DNA, RNA and protein biosynthesis and how their interactions are regulated. Genesis, a new source of precision medicine, has built the Illumina real-time PCR platform and the Sequenom mass spectrometry platform to help customers simultaneously perform technical services such as genotyping, methylation, and fluorescence quantification.
① genotyping services: genotyping refers to the use of gene chip typing technology in a very short period of time on a large number of SNP typing, and on this basis, a new generation of high-throughput sequencing technology in the common SNP In addition, a large number of rare mutations are found as well as mutations that are not found in the database to more effectively identify disease-associated variants.
② methylation services: methylation refers to the organism in the DNA methyltransferase catalysis, s-adenosylmethionine as a methyl donor, the transfer of methyl to a specific base of the process . Through DNA methylation processing, can cause changes in chromatin structure, DNA conformation, DNA stability and DNA and protein interactions, thus affecting gene expression.
③ Fluorescence quantitative service: Fluorescence quantification means adding fluorophores into the PCR reaction system, using fluorescence signal to accumulate real-time monitoring of the whole PCR process, and finally analyzing the unknown template by standard curve.